CVM is an inherited disease in (Holstein) cattle. CVM has been detected in stillborn or aborted calves. Affected calves have a reduced weight, abnormal spine and underdeveloped legs. Also heart abmornalities have been seen as a result of CVM. Affected calves are born dead, or reabsorbed during pregnancy. The disease has spread into many lines of cattle due to the fact that a major AI-sire was carrier of the disease.
Test specific information
This disease leads to a reduction in the number of liveborn offspring. Depending on the disease, affected individuals may be stillborn or aborted.
Normally the result can be expected within 15 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.
Location of disease or trait
This disease affects the formation of bone as well as the skeletal development.
For this test samples from all breeds are accepted.
For this DNA test we accept the following materials: Hair, Semen, Blood EDTA, Blood Heparin, Tissue. Please contact PharmaDNA if you wish to submit other material as listed.
An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will not become ill.An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will become ill.
This genetic factor is inherited in an autosomal, recessive, mode. This means, that the individual can be free of the disease (homozygote normal), affected (homozygous affected) or carrier (heterozygous). Carriers may spread the mutation in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a mutation.
Severity of Disease