Trapped Neutrophil Syndrome (TNS) is an inherited fatal immune disorder. Neutrophils are the precursors to white blood cells, produced in the bone marrow and, in a normal animal, released into the blood to fight infections. In a TNS affected animal these neutrophils cannot be released from the bone marrow so the animal is unable to mount an effective immune response to infection. Symptoms can vary greatly, depending on which infections the pup happens to contract. A bone marrow biopsy is the best way to detect the disease, if the neutrophil levels in the bone marrow are higher than those in the blood it is an indication that these are trapped hence trapped neutrophil syndrome.
Test specific information
Symptoms will develop at a young age. Within a few hours to a maximum of several weeks after birth, the characteristics that go with these genetic effects will become visible.
Normally the result can be expected within 15 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.
Location of disease or trait
This disease leads to reduced immunity. Depending on the disease, the immune system may be completely absent.
This DNA test is available for the following breeds: Border Collie, Bearded Collie, Rough Collies, Smooth Collies.
For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Tissue, Swab, Semen. Please contact PharmaDNA if you wish to submit other material as listed.
An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will not become ill.An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will become ill.
This genetic factor is inherited in an autosomal, recessive, mode. This means, that the individual can be free of the disease (homozygote normal), affected (homozygous affected) or carrier (heterozygous). Carriers may spread the mutation in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a mutation.
Severity of Disease