Background
Heritable polyneuropathies are a heterogenous group of diseases which affect the peripheral nervous system. In the Leonberger breed, the age-of-onset of clinical signs can vary from
Inheritance of LPN2 is incompletely dominant.
Test specific information
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Age
The disease may show itself on different ages, in which it cannot be estimated when the first symptoms may show themselves. Differences may exist between littermates, and between breeds.
Throughput
Normally the result can be expected within 15 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.
Location of disease or trait
This disease is present in the entire body, but causes main effects in the internal organs such as stomach, intestinal tract, liver and / or kidneys. In a number of cases, the disease affects one major internal organ.
Breed dependence
This DNA test is available for the following breeds: Leonberger.
Sample type
For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Tissue, Semen, Swab. Please contact PharmaDNA if you wish to submit other material as listed.
Result
Inheritance
This genetic factor is inherited in an autosomal, dominant, mode. This means, that the individual can be free of the mutation (homozygote normal), affected (homozygous affected) or carrier (heterozygous affected). Both carriers and affected individuals will show symptoms of the mutation.
Severity of Disease
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