Background
During the last decades, a large number of scientific publications have described the genetic principles of coat colour and coat variation. Coat colours and coat variations are influenced by many hereditary factors. The DNA-tests are based on physiological effects in the body, in which the production and distribution of pigments result in many coat colour variants. In several cases, the coat colour of an animal may only be decided using DNA-tests. Each horse has a basic colour, which can be black, bay/brown or chestnut. These basic coat colours are controlled by the Extension and Agouti genes. The Agouti gene (A-locus) controls the distribution of black pigment. The pigment can be uniformly distributed or distributed to the ?points? of the body (mane, tail, lower legs and inside the ears). The Agouti gene has no effect on horses that are homozygous ee for the Extension gene as black pigment has to be present for agouti to have an effect. The Coat Colour Agouti test (P907) tests for the genetic status of the Agouti gene. The Agouti gene has two variants (alleles). The dominant allele A restricts black pigment to the points of the horse (for example in bays and buckskins) and the recessive allele a uniformly distributes black pigment over the entire body. Only when the horse has two copies of the recessive allele a (homozygous aa), the black pigment is evenly distributed. The black pigment is distributed into the points if at least one copy of the allele A is present. All horses, regardless of their coat colour do have the genetics for the distribution of black pigment, but it?s not always physically visible.
Test specific information
This test is also included in a Combination Package Coat Colour.
Since 2015, two brands have been developed. CombiGen?
is mainly directed at veterinarian applications, whereas CombiBreed?
is mainly directed at breeders and/or owners.Detailed information about Coat Colours and Coat Variation is presented at www.pharmaDNA.com.
Age
Most coat colours and coat types are usually visible directly after birth.
Throughput
Normally the result can be expected within 15 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.
Location of disease or trait
Genetic factors influencing coat colours and coat types are usually visible on the outside of an individual. Several factors may be hidden by the external variation.
Breed dependence
For this test samples from all breeds are accepted.
Sample type
For this DNA test we accept the following materials: Hair, Semen, Blood EDTA, Blood Heparin, Tissue. Please contact PharmaDNA if you wish to submit other material as listed.
Result
Coat colours are based on many genetic factors. For each factor, a separate test result will be returned.
Inheritance
Various genetic factors influencing coat colour are inherited in a dominant or recessive mode. Coat colours are influenced by a large number of genetic factors.
Severity of Disease
Genetic characteristics are not a disease.
