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Dog DNA testing illustration

Intestinal Cobalamin Malabsorption (ICM, IGS) – Beagle

Code: H366

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Imerslund-Gräsbeck Syndrome (IGS), also known as Selective Intestinal Cobalamin Malabsorption (ICM), is a disorder in which the intestines fail to absorb enough Vitamin B12.

General information

Imerslund-Gräsbeck Syndrome (IGS), also known as Selective Intestinal Cobalamin Malabsorption (ICM), is a disorder in which the intestines fail to absorb enough Vitamin B12. This variant, found in the Beagle, is caused by a recessive mutation to the gene CUBN. Similar variants also occur in the Border Collie and Komondor.

Specifications

Breeds

Beagle
Gene

CUBN
Chromosome

2
Mutation

c.786delC
Organ

Digestive System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

I-GS

Clinical features

Symptoms for dogs affected by IGS can include lethargy, poor apetite and discomfort after eating, which can additonally result in in poor growth and/or weight loss. Urinary analysis may also reveal increased protein levels in the urine.

References

Pubmed ID: 24164695

Year published: 2014

Omia ID: 1786

Omia variant ID:

Turnaround information

  • 15 working days