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Dog DNA testing illustration

Intestinal Cobalamin Malabsorption (ICM, IGS) – Border Collie

Code: H367

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Imerslund-Gräsbeck Syndrome (IGS), also known as Selective Intestinal Cobalamin Malabsorption (ICM), is a disorder in which the intestines fail to absorb enough Vitamin B12.

General information

Imerslund-Gräsbeck Syndrome (IGS), also known as Selective Intestinal Cobalamin Malabsorption (ICM), is a disorder in which the intestines fail to absorb enough Vitamin B12. This variant, found in the Border Collie, is caused by a recessive mutation to the gene CUBN. Similar variants also occur in the Beagle and Komondor.

Specifications

Breeds

Border Collie
Gene

CUBN
Chromosome

2
Mutation

c.8392delC
Organ

Digestive System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

I-GS

Clinical features

Affected dogs start presenting within the first few weeks to months life with poor apetite and poor weight gain. Other symptoms may include difficulty swallowing, painful sores on the tongue, chronic diarrhea, heartbeat irregularities, anemia, and chronic fatigue.

References

Pubmed ID: 23613799

Year published: 2013

Omia ID: 1786

Omia variant ID:

Turnaround information

  • 15 working days