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Dog DNA testing illustration

Neuroaxonal Dystrophy (NAD) – Schnauzer and Beagle

Code: H428

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Neuroaxonal dystrophy (NAD) in dogs is a hereditary condition that affects the nervous system.

General information

Neuroaxonal dystrophy (NAD) in dogs is a hereditary condition that affects the nervous system. In the condition, there is swelling of cells in the brain which affect the communication with nerve cells. NAD can be present at birth or develop later in a dog’s life, leading to neurological dysfunction and loss of coordination.

There are multiple variants of mutations known in different breeds. This lethal variant of the disease, also known as Fetal-Onset Neuroaxonal Dystrophy (FNAD), was first observed in a Schnauzer and Beagle cross. It is caused by a recessive mutation to the gene MFN2.

Specifications

Breeds

Schnauzer (Giant), Beagle
Gene

MFN2
Chromosome

2
Mutation

c.1617_1619delGGA
Organ

Nervous System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

FNAD

Clinical features

Affected puppies are born with immobilized limb joints and with scoliosis of the spine. They are unable to breathe independently, and are either stillborn or die shortly after birth.

References

Pubmed ID: 20653033

Year published: 2010

Omia ID: 2153

Omia variant ID:

Turnaround information

  • 15 working days