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Dog DNA testing illustration

Neuronal Ceroid Lipofuscinosis 10 (NCL10) – American Bulldog

Code: H429

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Neuronal Ceroid Lipofuscinosis (NCL) is the name for a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death.

General information

Neuronal Ceroid Lipofuscinosis (NCL) is the name for a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. The variant analysed in this test, Neuronal Ceroid Lipofuscinosis 10 (NCL10), is caused by a recessive mutation to the gene CTSD. It is found in the Amerian Bulldog.

Specifications

Breeds

American Bulldog
Gene

CTSD
Chromosome

18
Mutation

c.597G>A
Organ

Nervous System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

NCL10

Clinical features

American Bulldogs develop clinical signs between 1 and 3 years of age and include mental dullness, ataxia, loss of vision, weakness, abnormal gait, seizures, tremors and aggressive behavior.

References

Pubmed ID: 16386934

Year published: 2006

Omia ID: 1505

Omia variant ID:

Turnaround information

  • 15 working days