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Dog DNA testing illustration

Congenital Hypothyroidism with Goiter (CHG) – Rat and Toy Fox Terrier

Code: H488

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Congenital hypothyroidism with goiter is observed to segregate as a simple autosomal recessive trait in Toy Fox Terriers (TFTs).

General information

Congenital hypothyroidism with goiter is observed to segregate as a simple autosomal recessive trait in Toy Fox Terriers (TFTs).

Neonatal affected pups show inactive behaviour, abnormal hair coat, delayed eye opening and stenotic ear canals. Palpable ventrolateral cervical swellings can be present by 1 week of age.

Rat Terriers are believed to have acquired more recently, as a result of interbreeding with Toy Fox Terriers.

Specifications

Breeds

Rat Terrier, Toy Fox Terrier
Gene

TPO
Chromosome

17
Mutation

c.331C>T
Organ

Endocrine glands
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

CHG

Clinical features

Typical clinical findings include growth retardation (disproportionate dwarfism) because of epiphyseal dysplasia, delay in maturation changes such as eyeopening and tooth eruption, abnormal hair and skin texture, mental retardation, and lethargy.

Additional information

Most hypothyroidism is not congenital. The disorder is lethal unless diagnosed and treated early.

References

Pubmed ID: 12564727

Year published: 2003

Omia ID: 536

Omia variant ID:

Turnaround information

  • 15 working days