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Polyneuropathy (AMPN) – Alaskan Malamute

Code: H495

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

Search by our number or the laboratory number. An unmatched number is saved as a previous / external reference. No new physical sample is needed.
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Short description

Polyneuropathy is a neurological disorder characterized by damage to the peripheral nerves.

General information

Polyneuropathy is a neurological disorder characterized by damage to the peripheral nerves. The variant of the disease analysed in this test is found in the Alaskan Malamute, and is known as Alaskan Malamute Polyneuropathy (AMPN). It is caused by a recessive mutation to the gene NDRG1. A related variant, GHPN, is found in the Greyhound.

Specifications

Breeds

Alaskan Malamute
Gene

NDRG1
Chromosome

13
Mutation

c.293G>T
Organ

Nervous System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive

Clinical features

Clinical features include weakness, numbness, and pain of the feet progressing to the legs and other body parts. The disease can be acute or chronic.

References

Pubmed ID: 23393557

Year published: 2013

Omia ID: 2120

Omia variant ID:

Turnaround information

  • 15 working days