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Dog DNA testing illustration

Warburg Micro Syndrome 1 (WARBM1)

Code: H696

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Warburg Micro Syndrome, type 1 (WARBM1) is a form of polyneuropathy, a severe degenerative nerve condition that causes vision problems, an altered voice, and lack of coordination.

General information

Warburg Micro Syndrome, type 1 (WARBM1) is a form of polyneuropathy, a severe degenerative nerve condition that causes vision problems, an altered voice, and lack of coordination. The onset starts at about four months of age, and affected dogs typically need to be euthanized on humane grounds within the first year. The disorder is caused by a recessive mutation to the gene RAB3GAP1, and is found in the Alaskan Husky (this test), and also the Black Russian Terrier and Rottweiler.

Specifications

Breeds

Alaskan Husky
Gene

RAB3GAP1
Chromosome

19
Mutation

c.614_615insLN864704:g.123_340
Organ

Nervous System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

ALPP

Clinical features

Onset of WARBM1 starts at 4 to 5 months of age with visual problems. Later, affected dogs experience paralysis of the larynx (resulting in an altered voice and vomiting), progressing to severe ataxia (loss of coordination) with an abnormal gait. Other symptoms include micropthalmia (abnormally small eyeballs), strabismus (lazy eyes), and cataracts .

References

Pubmed ID: 26596647

Year published: 2015

Omia ID: 1970

Omia variant ID:

Turnaround information

  • 15 working days