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Dog DNA testing illustration

X-Linked Severe Combined Immunodeficiency Disease (XSCID) – Cardigan Welsh Corgi

Code: H745

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Dogs affected by X-Linked Severe Combined Immunodeficiency Disease (X-SCID) have a poorly functioning immune system.

General information

Dogs affected by X-Linked Severe Combined Immunodeficiency Disease (X-SCID) have a poorly functioning immune system. This variant of the disorder is found in the Cardigan Welsh Corgi. The disease is caused by a recessive X-linked mutation to the gene IL2RG. Because affected dogs are unable to produce a protein important for proper immune function, they are extremely susceptible to bacterial, viral and yeast infections. Even with treatment, affected pups usually die by 4 months of age.

A related variant is found in the Basset Hound.

Specifications

Breeds

Cardigan Welsh Corgi
Gene

IL2RG
Chromosome

X
Mutation

c.583_584insC
Organ

Immune System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

X-Linked Recessive
Also known as

XSCID; X-SCID

Clinical features

Affected dogs often show symptoms around 6 to 8 weeks of age including failure to thrive, diarrhea, intermittent vomiting and absence of palpable lymph nodes. Affected dogs may also suffer from respiratory, skin, eye or ear infections. Vaccination of affected pups with modified live virus vaccines can cause viremia and clinical signs.

References

Pubmed ID: 8571541

Year published: 1995

Omia ID: 899

Omia variant ID:

Turnaround information

  • 15 working days