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Dog DNA testing illustration

Mucopolysaccharidosis VII (MPS7) – German Shepherd

Code: H748

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

Search by our number or the laboratory number. An unmatched number is saved as a previous / external reference. No new physical sample is needed.
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Short description

Mucopolysaccharidosis (MPS) is a class of metabolic disorders that typically cause severe neurological problems and other developmental issues.

General information

Mucopolysaccharidosis (MPS) is a class of metabolic disorders that typically cause severe neurological problems and other developmental issues. A variant of the disease, type VII (MPS VII, also known as Sly Syndrome) is caused by a recessive mutation to the gene GUSB. The specific variant analysed in this test is found in the German Shepherd. A related variant is also found in the Brazilian Terrier.

Specifications

Breeds

German Shepherd
Gene

GUSB
Chromosome

6
Mutation

c.497G>A
Organ

Respiratory System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

MPS VII

Clinical features

Affected dogs have symptoms such as ataxia, head tremors, swaying and abnormal eye movement. The clinical signs develop around the age of 3 years.

References

Pubmed ID: 9521879

Year published: 1998

Omia ID: 667

Omia variant ID:

Turnaround information

  • 15 working days