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Dog DNA testing illustration

Early Onset Progressive Polyneuropathy (EOPP)

Code: H914

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

Search by our number or the laboratory number. An unmatched number is saved as a previous / external reference. No new physical sample is needed.
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Short description

Polyneuropathy is a neurological disorder characterized by damage to the peripheral nerves.

General information

Polyneuropathy is a neurological disorder characterized by damage to the peripheral nerves. The variant of the disease analysed in this test is found in the Greyhound, and is known as Early Onset Progressive Polyneuropathy (EOPP) or
Greyhound Polyneuropathy (GHPN). It is caused by an autosomal recessive mutation to the gene NDRG1. A related variant, Alaskan Malamute Polyneuropathie (AMPN), is also offered as a seperate test.

Specifications

Breeds

Greyhound
Gene

NDRG1
Chromosome

13
Mutation

c.1080_1089del10
Organ

Nervous System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive

Clinical features

Clinical features include weakness, numbness, and pain of the feet progressing to the legs and other body parts. The disease can be acute or chronic and the first clinical signs can usually be observed between 3 and 9 months of age. In rare cases, it is only revealed after 7 months.

As the disease progresses, affected dogs may eventually require euthanasia for humane reasons due to loss of mobility and respiratory failure.

References

Pubmed ID: 20582309

Year published: 2010

Omia ID: 2120

Omia variant ID:

Turnaround information

  • 15 working days