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Dog DNA testing illustration

Paroxysmal Dyskinesia (PD) – Irish Soft Coated Wheaten Terrier

Code: H634

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Paroxysmal Dyskinesia (PxD) is a neurological condition that results in episodes of convulsions.

General information

Paroxysmal Dyskinesia (PxD) is a neurological condition that results in episodes of convulsions. The form of the disorder analysed in this test, found in the Soft-Coated Wheaten Terrier, is caused by a recessive mutation to the gene PIGN.

Specifications

Breeds

Irish Soft-Coated Wheaten Terrier
Gene

PIGN
Chromosome

1
Mutation

c.398C>T
Organ

Nervous System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive

Clinical features

Onset of PxD convulsive episodes in the SCWT occurs at about 2 years of age. The convulsions mainly affect the hind limbs, which rapidly flex and extend. Episodes can vary between minutes and hours in length, and can occur anywhere between multiple times a day, and once every few days. They may be triggered by stress, excitement or noise, but exact triggers are unclear. In some cases, symptoms can increase in severity until euthanasia on humane grounds is desirable.

References

Pubmed ID: 27891564

Year published: 2016

Omia ID: 2084

Omia variant ID:

Turnaround information

  • 15 working days