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Dog DNA testing illustration

Leukoencephalomyelopathy (LEMP) – Leonberger

Code: H892

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Leukoencephalomyelopathy (LEMP) is a severe, degenerative neural disorder that occurs in young dogs and causes a progressive loss of muscle coordination.

General information

Leukoencephalomyelopathy (LEMP) is a severe, degenerative neural disorder that occurs in young dogs and causes a progressive loss of muscle coordination. The disorder is caused by a recessive mutation to the gene NAPEPLD. The variant of LEMP analysed in this test occurs in the Leonberger. A related variant is found in the Great Dane and Rottweiler.

Specifications

Breeds

Leonberger
Gene

NAPEPLD
Chromosome

18
Mutation

c.538G>C
Organ

Nervous System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

LEMP

Clinical features

Onset of LEMP symptoms in affected dogs generally occurs between 1 and 2 years of age. Signs include ataxia (loss of coordination), knuckling and dragging of the paws, hypermetria (overextension of limbs while stepping) and reduced spinal reflexes. The disease progresses over a matter of months, and euthanasia on humane grounds is likely to be considered.

References

Pubmed ID: 29643404

Year published: 2018

Omia ID: 1788

Omia variant ID:

Turnaround information

  • 15 working days