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Dog DNA testing illustration

May-Hegglin Anomaly (MHA) – Pug

Code: H882

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

May-Hegglin Anomaly (MHA) is a blood disorder that causes the formation of abnormally-large platelets, which can result in symptoms such as skin lesions and lowered platelet counts.

General information

May-Hegglin Anomaly (MHA) is a blood disorder that causes the formation of abnormally-large platelets, which can result in symptoms such as skin lesions and lowered platelet counts. This variant of the disease, caused by a dominant mutation to the gene MYH9, has been observed in the Pug.

Specifications

Breeds

Pug
Gene

MYH9
Chromosome

10
Mutation

c.5521G>A
Organ

Multiple systems
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Dominant
Also known as

MHA

Clinical features

Affected dogs display thrombocytopenia (lowered blood platelet counts), but might not necessarily develop any bleeding problems. Additionally, an affected dog may develop skin lesions and white plaques in the mouth following immunosuppressive treatment.

References

Pubmed ID: 21554370

Year published: 2011

Omia ID: 1608

Omia variant ID:

Turnaround information

  • 15 working days