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Dog DNA testing illustration

Intestinal Cobalamin Malabsorption (ICM, IGS) – Komondor

Code: H955

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Imerslund-Gräsbeck Syndrome (IGS), also known as Selective Intestinal Cobalamin Malabsorption (ICM), is a disorder in which the intestines fail to absorb enough Vitamin B12.

General information

Imerslund-Gräsbeck Syndrome (IGS), also known as Selective Intestinal Cobalamin Malabsorption (ICM), is a disorder in which the intestines fail to absorb enough Vitamin B12. This variant, caused by a recessive mutation to the gene CUBN, is found in the Komondor. Closely related variants also occur in the Border Collie and Beagle.

Specifications

Breeds

Komondor
Gene

CUBN
Chromosome

2
Mutation

c.8746+1G>A
Organ

Digestive System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

I-GS

Clinical features

Vitamin B12 deficiency caused by IGS becomes apparent in affected puppies between 2 and 5 months of age. Symptoms include lack of appetite, failure to thrive, weakness, vomiting, diarrhoea and possibly tremors and seizures.

References

Pubmed ID: 30591068

Year published: 2018

Omia ID: 1786

Omia variant ID:

Turnaround information

  • 15 working days