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Dog DNA testing illustration

Cardiac Laminopathy (CLAM) – Nova Scotia Duck Tolling Retriever

Code: H296

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Cardiac Laminopathy (CLAM), a fatal heritable condition, has been described in the Nova Scotia Duck Tolling Retriever.

General information

Cardiac Laminopathy (CLAM), a fatal heritable condition, has been described in the Nova Scotia Duck Tolling Retriever. This variant is caused by a recessive mutation to the gene LMNA. CLAM can result in Dilated Cardiomyopathy (DCM), which is a disorder characterised by enlargement of the heart (especially of the left ventricle), poor myocardial contractility, and congestive heart failure.

Specifications

Breeds

Nova Scotia Duck Tolling Retriever
Gene

LMNA
Chromosome

7
Mutation

c.1726delG
Organ

Cardiovascular System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

CLAM; DCM

Clinical features

Affected dogs can develop DCM within the first year of life. Symptoms of DCM can include lack of appetite, lethargy, and irregular or otherwise abnormal heart rhythm. Affected dogs may ultimately die of sudden heart failure.

References

Pubmed ID: 37925523

Year published: 2023

Omia ID: 2796

Omia variant ID:

Turnaround information

  • 15 working days