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Dog DNA testing illustration

Progressive Retinal Atrophy (crd1-PRA) – American Staffordshire Terrier

Code: H357

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Cone-Rod Dystrophy (CRD) is a disorder of the photoreceptor cells of the eye, which can lead to early-onset blindness in affected dogs.

General information

Cone-Rod Dystrophy (CRD) is a disorder of the photoreceptor cells of the eye, which can lead to early-onset blindness in affected dogs. This variant of the disorder, Cone-Rod Dystrophy, Type 1 (crd1, or crd1-PRA) is found in the American Staffordshire Terrier. It is caused by a recessive mutation to the gene PDE6B. A similar variant of the disease, called crd2, occurs in the Pit Bull Terrier.

Specifications

Breeds

American Staffordshire Terrier
Gene

PDE6B
Chromosome

3
Mutation

c.2404_2406del
Organ

Sensory organs
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

crd1-PRA

Clinical features

Affected dogs have progressively degenerating retinas, which grow thinner and more “ragged” within the first few months after birth. They will display severe vision impairment in both well-lit and dimly-lit conditions, which can progress to more severe blindness within the first year of age.

References

Pubmed ID: 24045995

Year published: 2013

Omia ID: 1674

Omia variant ID:

Turnaround information

  • 15 working days