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Dog DNA testing illustration

Primary Ciliary Dyskinesia (PCD) – Old English Sheepdog

Code: H414

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Primary ciliary dyskinesia (PCD) is caused by a genetic mutation (CCD39 gene) that affects the cilia of cells.

General information

Primary ciliary dyskinesia (PCD) is caused by a genetic mutation (CCD39 gene) that affects the cilia of cells. The cilia (microscopic hair-like projections of cells that are able to move) play a role in the respiratory tract to remove bacteria and foreign material from the respiratory tract and helping to protect the lungs. And the cilia play a role in the reproductive tract.

Specifications

Breeds

Old English Sheepdog
Gene

CCDC39
Chromosome

34
Mutation

c.286C>T
Organ

Respiratory System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

PCD

Clinical features

Dogs affected by primary ciliary dyskinesia show recurrent upper and lower respiratory tract infections (most importantly pneumonia). Affected dogs tend to have lower fertility due to the malfunction of the cilia. Signs are first seen in the first few days or weeks of life, with young puppies developing a mucoid nasal discharge and/or pneumonia.

References

Pubmed ID: 21131972

Year published: 2011

Omia ID: 1540

Omia variant ID:

Turnaround information

  • 15 working days