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Dog DNA testing illustration

Glanzmann’s Thrombasthenia (GT) 2 – Dog

Code: H447

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

Search by our number or the laboratory number. An unmatched number is saved as a previous / external reference. No new physical sample is needed.
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Short description

Glanzmann’s Thrombasthenia (GT) is a bleeding disorder caused by defective platelets, which can result in uncontrolled bleeding.

General information

Glanzmann’s Thrombasthenia (GT) is a bleeding disorder caused by defective platelets, which can result in uncontrolled bleeding. This variant of the disease, Type I Glanzmann’s Thrombasthenia, is caused by a recessive mutation to the gene ITGA2B. It is observed in the Great Pyrenees. A related variant is found in the Scottish Deerhound.

Specifications

Breeds

Great Pyrenees
Gene

ITGA2B
Chromosome

9
Mutation

c.1360_1373dup
Organ

Cardiovascular System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Incomplete Dominant

Clinical features

Affected dogs are susceptible to excessive bleeding, such as nosebleeds or bleeding from the gums during tooth eruption. Blood analysis will show normal platelet counts but minimal platelet activity.

References

Pubmed ID: 11105947

Year published: 2000

Omia ID: 1000

Omia variant ID:

Turnaround information

  • 15 working days