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Horse DNA testing illustration

Occipitoatlantoaxial Malformation – OAAM

Code: P314

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Occipitoatlantoaxial Malformation (OAAM), also known as Atlanto-Occipital Fusion, is a skeletal defect which causes the first cervical vertebra (atlas) to resemble the base of the skull (occiput), and the second cervical vertebra (axis) to resemble the atlas.

General information

Occipitoatlantoaxial Malformation (OAAM), also known as Atlanto-Occipital Fusion, is a skeletal defect which causes the first cervical vertebra (atlas) to resemble the base of the skull (occiput), and the second cervical vertebra (axis) to resemble the atlas. The disorder is found in the Arabian horse, and is caused by a recessive mutation to the gene HOXD3.

Specifications

Breeds

Arabian
Gene

HOXD3
Chromosome

18
Organ

Skeletal system
Specimen

Hair, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

OAAM

Clinical features

Clinical features include abnormal head position, progressive ataxia, extended neck posture and visible unevenness along the cervical spine. OAAM affects the mobility of the neck, which is characterised as loss of extension and flexibility. Affected foals may be stillborn, and surviving horses are likely to develop defects such as ataxia and tetraparesis.

References

Pubmed ID: 28111759

Year published: 2017

Omia ID: 81

Omia variant ID:

Turnaround information

  • 15 working days