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Dog DNA testing illustration

Macular Corneal Dystrophy (MCD)

Code: H317

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Macular Corneal dystrophy (MCD) is an eye condition in Labrador Retrievers that causes the corneas to gradually become cloudy, leading to worsening vision.

General information

Macular Corneal dystrophy (MCD) is an eye condition in Labrador Retrievers that causes the corneas to gradually become cloudy, leading to worsening vision. It is most likely caused by a recessive mutation in a comparative candidate gene (CHST6), which is also called LOC489707.

Specifications

Breeds

Australian Labradoodle, Labrador Retriever
Gene

LOC489707
Chromosome

5
Mutation

c.814C>A
Organ

Sensory organs
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

MCD

Clinical features

Onset of MCD is generally between 4.5 and 6 years of age. The cornea becomes gradually cloudy, and develops multiple off-white to yellow-brown opaque spots of varying sizes. Affected dogs may show signs of impaired vision, though complete blindness is generally uncommon.

References

Pubmed ID: 26585178

Year published: 2016

Omia ID: 2071

Omia variant ID:

Turnaround information

  • 15 working days