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Dog DNA testing illustration

Hereditary Footpad Hyperkeratosis (FAM83G-related)

Code: H492

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder of the footpads, which causes the development of thick, painful, callus-like growths.

General information

Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder of the footpads, which causes the development of thick, painful, callus-like growths. This variant of the disease, known as Palmoplantar Hyperkeratosis or Digital Hyperkeratosis (DH), is found in the Irish Terrier and Kromfohrländer. It is caused by a recessive mutation to the gene FAM83G.

Specifications

Breeds

Bedlington Terrier, Irish Terrier, Kromfohrländer
Gene

FAM83G
Chromosome

5
Mutation

c.155G>C
Organ

Integumentary System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

HFH; DH

Clinical features

HFH initially leads to thickened and hardened footpads. It involves all footpads and is noticed at 4–5 months of age. Subsequently, the inelastic pad surface develops cracks and fissures, which predispose affected dogs to secondary infections. The nails of affected dogs are very hard and seem to grow faster. Affected animals avoid walking on irregular surfaces and if not properly managed, HFH can lead to considerable pain and lameness.

References

Pubmed ID: 24832243

Year published: 2014

Omia ID: 1327

Omia variant ID:

Turnaround information

  • 15 working days