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Dog DNA testing illustration

Trapped Neutrophil Syndrome (TNS)

Code: H787

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Trapped Neutrophil Syndrome (TNS) is a hereditary immune disease common to Border Collies.

General information

Trapped Neutrophil Syndrome (TNS) is a hereditary immune disease common to Border Collies. Affected dogs’ bone marrow is unable to properly release white blood cells into the bloodstream, causing various bodily complications as well as an extreme vulnerability to infections due to a poor immune system. TNS is therefore often fatal within the first year. It is caused by a recessive mutation to the gene VPS13B.

Specifications

Breeds

Border Collie
Gene

VPS13B
Chromosome

13
Mutation

c.2893_2896del
Organ

Cardiovascular System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

TNS

Clinical features

Affected puppies suffer from infections due to a compromised immune system. They are smaller and weaker than their littermates, and may develop an abnormally lengthened head and/or legs. Onset can be anywhere between six months and two years of age.

References

Pubmed ID: 21605373

Year published: 2011

Omia ID: 1428

Omia variant ID:

Turnaround information

  • 15 working days