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Cat DNA testing illustration

Osteochondrodysplasia – Scottish Fold

Code: K399

74,72 €

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Short description

Scottish Fold cats, named for their unique ear shape, show both straight and folded ear phenotypes.

General information

Scottish Fold cats, named for their unique ear shape, show both straight and folded ear phenotypes. The fold type results from a dominant mutation to the gene TRPV4.

This mutation also affects cartilage development, causing a congenital osteochondrodysplasia. All fold kittens are born with straight ears, folding of the ears starts as early as 3 weeks of age. Ear folding is a consistent feature, the age of onset and progression of osteochondrodysplasia is highly variable.

Specifications

Breeds

Scottish fold
Gene

TRPV4
Chromosome

D3
Mutation

c.1024G>T
Organ

Skeletal system
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Incomplete Dominant

Clinical features

Folded ears and osteochondrodysplasia involving cartilage- and bone-related health problems including misshapen toes, thickened and inflexible tails, and accelerated progressive osteoarthritis. Age of onset and progression of osteochondrodysplasia is highly variable. Cats with two copies of the fold mutation are prone to more extreme health problems affecting cartilage and bone.

References

Pubmed ID: 27063440

Year published: 2016

Omia ID: 319

Omia variant ID:

Turnaround information

  • 15 working days