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Dog DNA testing illustration

Sensory Neuropathy – All breeds

Code: H695

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Sensory neuropathy (SN) is a severe neurological disease caused by a recessive mutation in the FAM134B gene.

General information

Sensory neuropathy (SN) is a severe neurological disease caused by a recessive mutation in the FAM134B gene. Animals with the disease show degeneration of sensory nerve cells and motor nerve cells.

This variant is for all breeds.

Specifications

Breeds

All Breeds
Gene

FAM134B
Chromosome

4
Mutation

c.656C>T
Organ

Nervous System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

SN

Clinical features

Affected puppies manifest at approximately 7 months of age with ataxia (loss of coordination) in the limbs. The disease progresses to cause loss of sensation, "knuckling" of the hind paws and self-mutilation of the paws, which often necessitates surgical amputation of damaged toes.

References

Pubmed ID: 34387380

Year published: 2021

Omia ID: 2032

Omia variant ID:

Turnaround information

  • 15 working days