Dilated Cardiomyopathy (DCM4) – Doberman
Code: H881
Short description
Dilated Cardiomyopathy (DCM) is a disorder characterised by enlargement of the heart (especially of the left ventricle), poor myocardial contractility, and congestive heart failure.
General information
Dilated Cardiomyopathy (DCM) is a disorder characterised by enlargement of the heart (especially of the left ventricle), poor myocardial contractility, and congestive heart failure. This specific test detects a mutation to the gene RNF207, which is one of several that is associated with the disease in the Doberman.
Specifications
| Breeds | |
|---|---|
| Gene | RNF207 |
| Chromosome | 5 |
| Mutation | c.1297-1G>A |
| Organ | Cardiovascular System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Multifactorial |
| Also known as | DCM |
Clinical features
DCM is an enlargement of the heart that can result in decreased heart function and abnormal heart rhythm. Clinical signs of heart failure due to DCM include fainting or collapse, weight loss, breathlessness, fluid retention in the abdomen, and sudden death due to cardiac arrest.
Additional information
The mutation in this test should be considered a risk factor. It is associated with the disorder, but does not necessarily guarantee it.
References
Pubmed ID: 37723491
Year published: 2023
Omia ID: 162
Omia variant ID:
Turnaround information
- 15 working days