Skip to main content

Address

Panerių g. 246
48454 Kaunas
Lithuania

Opening hours

  • Mon – Fri
    9 :00 – 17 00
  • Sat
    Closed    
  • Sun
    Closed   
Dog DNA testing illustration

Neuroaxonal Dystrophy (NAD) – Miniature American Shepherd

Code: H289

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

Search by our number or the laboratory number. An unmatched number is saved as a previous / external reference. No new physical sample is needed.
The add to cart button will appear once you select the values above

Short description

Neuroaxonal dystrophy (NAD) in dogs is a hereditary condition that affects the nervous system.

General information

Neuroaxonal dystrophy (NAD) in dogs is a hereditary condition that affects the nervous system. In the condition, there is swelling of cells in the brain which affect the communication with nerve cells. NAD can be present at birth or develop later in a dog’s life, leading to neurological dysfunction and loss of coordination.

There are multiple variants of mutations known in different breeds. In the Toy Australian Shepherd and Miniature American Shepherd, a variant of the disorder has been observed which is probably caused by a recessive mutation to the gene RNF170.

Specifications

Breeds

Miniature American Shepherd, Toy Australian Shepherd
Gene

RNF170
Chromosome

16
Mutation

c.367delG
Organ

Nervous System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

NAD

Clinical features

Affected dogs display slowly progressive neurological signs which can include ataxia (loss of coordination), weakness of the hind limbs, dragging of the toes while walking, seizures, and fearful behaviour.

References

Pubmed ID: 39177409

Year published: 2024

Omia ID: 2876

Omia variant ID:

Turnaround information

  • 15 working days