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Dog DNA testing illustration

Hereditary Nephritis (HN) – Samoyed

Code: H370

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Canine Hereditary Nephritis (HN) is a group of hereditary glomerular diseases of the kidneys, which often progress to renal failure.

General information

Canine Hereditary Nephritis (HN) is a group of hereditary glomerular diseases of the kidneys, which often progress to renal failure. X-linked nephritis is caused by mutations in the alpha 5 chain of collagen type IV (COL4A5). This variant of the disorder is found in the Samoyed. A related variant has also been observed in the Navasota dog.

Specifications

Breeds

Samoyed
Gene

COL4A5
Chromosome

X
Mutation

c.3079G>T
Organ

Respiratory System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

X-Linked
Also known as

HN

Clinical features

Clinical signs include for affected dogs include proteinuria and the development of rapidly progressive renal failure. The symptoms are usually fatal before 1 year of age. Approximately 31% of the carrier female Samoyeds develop mild renal disease, and 38% progress to the final stage of the renal disease.

References

Pubmed ID: 8171024

Year published: 1994

Omia ID: 1112

Omia variant ID:

Turnaround information

  • 15 working days