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Dog DNA testing illustration

Sensory Neuropathy – Border Collie

Code: H388

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Sensory neuropathy (SN) is a severe neurological disease caused by a recessive mutation in the FAM134B gene.

General information

Sensory neuropathy (SN) is a severe neurological disease caused by a recessive mutation in the FAM134B gene. Animals with the disease show degeneration of sensory nerve cells and motor nerve cells.

This variant is for the Border Collie.

Specifications

Breeds

Border Collie
Gene

FAM134B
Chromosome

4
Organ

Nervous System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

SN

Clinical features

The first clinical signs of SN present between 2 and 7 months of age. The first visible signs are progressive proprioceptive ataxia with intermittent "knuckling" of the paws, hyperextension of the limbs, and self-mutilation wounds on and around the paws. Generally, the hind limbs are more severely affected than the front limbs. Later stages can also involve loss of sensation, and urinary incontinence.

Additional information

Other/mixed breeds with border collie ancestors can also be affected.

References

Pubmed ID: 27527794

Year published: 2016

Omia ID: 2032

Omia variant ID:

Turnaround information

  • 20 working days