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Dog DNA testing illustration

Canine Scott Syndrome (CSS)

Code: H392

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Canine Scott Syndrome (CSS), also called Platelet Factor X Receptor Deficiency or Hemorrhagic Diathesis, is caused by a defect in platelet function.

General information

Canine Scott Syndrome (CSS), also called Platelet Factor X Receptor Deficiency or Hemorrhagic Diathesis, is caused by a defect in platelet function. Platelets, also called thrombocytes, play an important role in blood coagulation. The disease is caused by a recessive mutation to the gene ANO6.

Specifications

Breeds

German Shepherd
Gene

ANO6
Chromosome

27
Mutation

c.1934+1G>A
Organ

Cardiovascular System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

CSS; Canine Scott Syndrome

Clinical features

In dogs with CSS, common symptoms include postoperative bruising and hematoma formation at surgical sites. While these symptoms are usually mild, life-threatening bleeding after surgery has been reported. As a result, affected dogs may require blood or platelet transfusions during surgery. If surgery is planned, it is important to inform the veterinarian. Nonsurgical bleeding can also occur, including recurrent episodes of epistaxis (nosebleeds) and bleedings affecting the joints or soft tissues. Despite the bleeding tendency, affected dogs are expected to have a normal lifespan.

References

Pubmed ID: 26414452

Year published: 2015

Omia ID: 1353

Omia variant ID:

Turnaround information

  • 15 working days