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Dog DNA testing illustration

Gray Collie Syndrome (Cyclic Neutropenia)

Code: H752

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Cyclic Neutropenia is a stem cell disease, which is characterised by cyclic fluctuations in leukocyte numbers, especially the neutrophils.

General information

Cyclic Neutropenia is a stem cell disease, which is characterised by cyclic fluctuations in leukocyte numbers, especially the neutrophils.
In dogs the disease is also known as cyclic hematopoiesis or Grey/Gray Collie Syndrom. In humans known as Hermansky-Pudlak Syndrome 2 (HPS-2).

Specifications

Breeds

Smooth Collie, Rough Collie
Gene

AP3B1
Chromosome

3
Mutation

c.2401_2402insA
Organ

Cardiovascular System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

Cyclic hematopoiesis. Grey/gray collie syndrom

Clinical features

Affected animals have an associated coat colour dilution, causing a gray coat colour. The cyclic neutropenia is associated with symptoms as recurrent fever, anorexia and severe - often life threathening - infections.

References

Pubmed ID: 12897784

Year published: 2003

Omia ID: 248

Omia variant ID:

Turnaround information

  • 15 working days