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Cat DNA testing illustration

Autoimmune Lymphoproliferative Syndrome – ALPS

Code: K310

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Autoimmune Lymphoproliferative Syndrome (ALPS) or Feline Autoimmune Lymphoproliferative Syndrome (FALPS) is a rare autosomal dominant disease in British Shorthair cats and related breeds that is caused by a mutation in the FASL gene.

General information

Autoimmune Lymphoproliferative Syndrome (ALPS) or Feline Autoimmune Lymphoproliferative Syndrome (FALPS) is a rare autosomal dominant disease in British Shorthair cats and related breeds that is caused by a mutation in the FASL gene. ALPS is characterized by an accumulation of immune cells in lymph nodes and spleen, causing enlargement of these tissues. The disease is fatal within weeks, with affected kittens either dying or being euthanized.

Specifications

Breeds

British Shorthair
Gene

FASLG
Chromosome

F1
Mutation

c.413_414insA
Organ

Immune System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

ALPS

Clinical features

Kittens with ALPS start showing symptoms at around 6-8 weeks of age. Affected kittens develop enlarged lymphnodes, enlarged spleen and can also display swelling of the abdomen, anaemia, lethargy, and weight loss.

References

Pubmed ID: 27770190

Year published: 2017

Omia ID: 2064

Omia variant ID:

Turnaround information

  • 15 working days