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Dog DNA testing illustration

Hereditary Footpad Hyperkeratosis (DSG1-related) – Rottweiler

Code: H777

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder of the footpads, which causes the development of thick, painful, callus-like growths.

General information

Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder of the footpads, which causes the development of thick, painful, callus-like growths. This variant of the disorder, found in the Rottweiler, is caused by a recessive mutation to the gene DSG1. The disorder is also known as Palmoplantar Hyperkeratosis.

Specifications

Breeds

Rottweiler
Gene

DSG1
Chromosome

7
Mutation

c.2541_2545delGGGCT
Organ

Integumentary System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

HFH

Clinical features

Symptoms for HFH affected dogs start at about 8 weeks of age, with footpads appearing unusually dry. The pads develop thick, rapidly-growing horny growths, which are painful and can cause additional discomfort while standing. The condition may also leave the dog more susceptible to additional skin and ear infections.

References

Pubmed ID: 32344723

Year published: 2020

Omia ID: 2266

Omia variant ID:

Turnaround information

  • 15 working days