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Dog DNA testing illustration

Ichthyosis – Great Dane

Code: H304

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

Search by our number or the laboratory number. An unmatched number is saved as a previous / external reference. No new physical sample is needed.
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Short description

Ichthyosis is not one but rather a group of skin disorders characterised by noninflammatory scaling of the skin.

General information

Ichthyosis is not one but rather a group of skin disorders characterised by noninflammatory scaling of the skin. Many different metaphors have been used to describe the appearance and texture of the skin in the various types and stages of ichthyosis, for example fish skin.

This variant of the disorder, which occurs in the Great Dane, is caused by a recessive mutation to the gene SLC27A4.

Specifications

Breeds

Great Dane
Gene

SLC27A4
Chromosome

9
Mutation

c.1250G>A
Organ

Integumentary System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive

Clinical features

Clinical signs of affected dogs are a generalized severe hyperkeratosis in all cases with a formation of a strongly wrinkled, thickened and scaling skin especially in the region of the eyes and nose.

Additional information

This test detects only one mutation. Therefore a dog can still develop ichthyosis as a result of (unknown) other mutations.

References

Pubmed ID: 26506231

Year published: 2015

Omia ID: 1973

Omia variant ID:

Turnaround information

  • 15 working days