Progressive Retinal Atrophy (bPRA) – Bengal
Code: K316
Short description
Progressive Retinal Atrophy (PRA) is a large group of genetic diseases in which the retina gradually degenerates over time, causing a progressive loss of vision.
General information
Progressive Retinal Atrophy (PRA) is a large group of genetic diseases in which the retina gradually degenerates over time, causing a progressive loss of vision. This variant of the disease, known as bPRA, occurs occurs in the Bengal, Savannah and Toyger breeds. It is caused by a recessive mutation to the gene KIF3B.
Specifications
| Breeds | |
|---|---|
| Gene | KIF3B |
| Chromosome | A3 |
| Mutation | c.1000G>A |
| Organ | Sensory organs |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | bPRA |
Clinical features
Cats with Progressive Retinal Atrophy (PRA) can show symptoms at an early age (a few weeks after birth). The symptoms progress slowly and cats can have very compromised vision by approximately 2 years of age. Blind cats tend to have changes in behaviour (e.g. more vocal and more attached to their owners). Their pupils are usually more dilated in lighting conditions and affected cats also tend to carry their whiskers in a more forward position.
References
Pubmed ID: 32386558
Year published: 2020
Omia ID: 2267
Omia variant ID:
Turnaround information
- 15 working days