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Dog DNA testing illustration

Exfoliative Cutaneous Lupus Erythematosus (ECLE)

Code: H980

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Exfoliative Cutaneous Lupus Erythematosus (ECLE) is a severe immune disorder affecting the skin, causing skin lesions, crusts and hair loss.

General information

Exfoliative Cutaneous Lupus Erythematosus (ECLE) is a severe immune disorder affecting the skin, causing skin lesions, crusts and hair loss. The disease is caused by a recessive mutation to the gene UNC93B1, and is found in the German Shorthaired Pointer, Vizsla and related hunting dogs.

Specifications

Breeds

Shorthaired Vizsla, Wirehaired Vizsla, German longhaired pointer, German Shorthaired Pointer
Gene

UNC93B1
Chromosome

18
Mutation

c.1438C>A
Organ

Integumentary System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

ECLE

Clinical features

Affected dogs present between the ages of 6 months and 3 years with the formation of skin scales, mainly on the face, ears and back. The skin may develop patchy, reddened lesions and clinging crusts, as well as general hair loss on affected areas. In later stages, some affected dogs may also experience severe joint pain.

References

Pubmed ID: 32028618

Year published: 2020

Omia ID: 1609

Omia variant ID:

Turnaround information

  • 15 working days