Ichthyosis – American Bulldog Type
Code: H378
Short description
Ichthyosis is a disease of the skin, causing itch, hair loss and the formation of dry, flaky “scales”.
General information
Ichthyosis is a disease of the skin, causing itch, hair loss and the formation of dry, flaky “scales”. It also leaves the skin vulnerable to yeast infection. This variant of the disorder, known as Autosomal Recessive Congenital Ichthyosis (ARCI) is found in the American Bulldog and American Bully. It is caused by a recessive mutation to the gene NIPAL4.
Specifications
| Breeds | |
|---|---|
| Gene | NIPAL4 |
| Chromosome | 4 |
| Organ | Integumentary System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | ARCI |
Clinical features
Affected puppies present within the first few weeks after birth with dishevelled coats, white or brown scaling and reddened skin with brown discolorations. The condition may worsen slightly as the dog grows to adulthood, and may be complicated by yeast infection by e.g. Malassezia yeast. Malassezia infection can in turn cause an unpleasant odour.
Additional information
This test only detects one mutation therefore a dog can still develop ichthyosis from other mutations.
References
Pubmed ID: 28122049
Year published: 2017
Omia ID: 1980
Omia variant ID:
Turnaround information
- 15 working days