Factor VII deficiency
Code: H435
Short description
Canine Coagulation Factor VII is an important protein involved in blood clotting in dogs.
General information
Canine Coagulation Factor VII is an important protein involved in blood clotting in dogs. Deficiency in Factor VII causes a bleeding disorder, which can lead to dangerously uncontrolled bleeding in the case of injury or surgery. The disorder occurs in a wide range of breeds, including the Airedale Terrier, Beagle, German Wirehaired Pointer and Scottish Deerhound. It is caused by a recessive mutation to the gene F7.
Specifications
| Breeds | Alaskan Klee Kai, Catahoula Leopard Dog, Japanese Spitz, Redbone Coonhound, Schnauzer (Giant), Schnauzer (Miniature), Sealyham Terrier, Welsh Springer Spaniel, Airedale Terrier, English Foxhound, Harrier, Irish Water Spaniel, Alaskan Husky, American Foxhound, Basset Hound, Beagle, Dachshund, Finnish Hound, German Shorthaired Pointer, German Wirehaired Pointer, Papillon, Phalène, Scottish Deerhound, Whippet |
|---|---|
| Gene | F7 |
| Chromosome | 22 |
| Mutation | c.407G>A |
| Organ | Cardiovascular System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
Clinical features
Under most circumstances, affected dogs appear healthy. However, they may bleed excessively after trauma or surgery, develop hematomas or bleeding in the body cavity, or experience persistent uterine or vaginal bleeding. Blood analysis can confirm a lack of Factor VII activity.
References
Pubmed ID: 16961583
Year published: 2006
Omia ID: 361
Omia variant ID:
Turnaround information
- 15 working days