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Dog DNA testing illustration

CLAD (Canine Leukocyte Adhesion Deficiency) Type III – German Shepherd

Code: H484

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Canine Leukocyte Adhesion Deficiency (CLAD) is a disorder of white blood cells and platelets that causes increased susceptibility to infections and bleeding tendencies.

General information

Canine Leukocyte Adhesion Deficiency (CLAD) is a disorder of white blood cells and platelets that causes increased susceptibility to infections and bleeding tendencies. This variant of the disease, CLAD Type III, is caused by a recessive mutation in FERMT3, which causes malfunctioning of white blood cells and platelets. The variant is found in the German Shepherd.

Specifications

Breeds

German Shepherd
Gene

FERMT3
Chromosome

18
Mutation

c.1349_1350insAAGACGGCTGCC
Organ

Immune System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

LAD3

Clinical features

In dogs that suffer of Canine Leucocyte Adhesion Deficiency type III, the healing capacities are impaired. Affected dogs are highly vulnerable to infection. They are likely to die early in life from multiple severe infections, even if treated with massive doses of antibiotics.

References

Pubmed ID: 20126836

Year published: 2010

Omia ID: 1525

Omia variant ID:

Turnaround information

  • 15 working days