Polycystic Kidney Disease (PKD) – Bull Terrier
Code: H509
Short description
Polycystic Kidney Disease (PKD) is a common condition in animals, characterized by the development of cysts in the kidneys over the animal's lifetime.
General information
Polycystic Kidney Disease (PKD) is a common condition in animals, characterized by the development of cysts in the kidneys over the animal’s lifetime. These cysts exert pressure on healthy kidney tissue, leading to a loss of kidney function. The disease results from an autosomal dominant mutation in the PKD1 gene and is observed in Bull Terriers, where it is also known as Bull Terrier PKD (BTPKD).
Specifications
| Breeds | |
|---|---|
| Gene | PKD1 |
| Chromosome | 6 |
| Mutation | c.9559G>A |
| Organ | Urinary system |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Dominant |
| Also known as | PKD |
Clinical features
PKD causes a progressive decline in kidney function, with symptoms typically appearing in adulthood. Common symptoms include loss of appetite, excessive drinking and urination, vomiting, and lethargy. In Bull Terriers with PKD, the disease may also lead to hypertension (high blood pressure). This is likely due to an increased prevalence of cardiac conditions in dogs with this variant of PKD including mitral valve disease (MVD) and potentially severe left ventricular outflow tract obstruction (LVOTO).
References
Pubmed ID: 21818326
Year published: 2011
Omia ID: 807
Omia variant ID:
Turnaround information
- 15 working days