Narcolepsy – Labrador Retriever
Code: H698
Short description
As in humans, Narcolepsy in dogs is a long-term sleep disorder resulting in lethargy and sudden bouts of sleep.
General information
As in humans, Narcolepsy in dogs is a long-term sleep disorder resulting in lethargy and sudden bouts of sleep. Canine narcolepsy is a recessive disorder caused by a mutation to the HCRTR2 gene. The variant analysed in this test is found in the Labrador Retriever. Related variants occur in the Doberman Pinscher and the Dachshund.
Specifications
| Breeds | |
|---|---|
| Gene | HCRTR2 |
| Chromosome | 12 |
| Mutation | c.1105+5G>A |
| Organ | Nervous System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | canarc-1 |
Clinical features
Narcolepsy is neither progressive nor life-threatening. Narcolepsy affected canines may show signs between 4 weeks to 6 months of age. Affected canine fall asleep faster than normal dogs and cannot stay awake for an extended period of time. In respons to emotional stimulus, affected canines may experience cataplexy: a sudden loss of muscle tone without loss of consciousness. First signs of cataplexy are buckling of both hindlimbs and drooping of the neck.
References
Pubmed ID: 10458611
Year published: 1999
Omia ID: 703
Omia variant ID:
Turnaround information
- 15 working days