Malignant Hyperthermia (MH) – Dog
Code: H746
Short description
Malignant Hyperthermia (MH) is a disorder that affects skeletal muscle function during anaesthesia.
General information
Malignant Hyperthermia (MH) is a disorder that affects skeletal muscle function during anaesthesia. It typically remains unnoticed unless triggered, most often by certain anesthetic drugs. When activated, it can cause a rapid and severe reaction involving abnormal muscle activity and dangerously accelerated metabolism. MH is caused by a mutation in the RYR1 gene and is inherited in an autosomal dominant manner. This mutation has been identified in several breeds, including Doberman, Labrador Retriever, Rough Collie, Smooth Collie and German Shepherd.
Specifications
| Breeds | Smooth Collie, Doberman, German Shepherd, Labrador Retriever, Rough Collie |
|---|---|
| Gene | RYR1 |
| Chromosome | 1 |
| Mutation | c.1640T>C |
| Organ | Multiple systems |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Dominant |
| Also known as | MHS |
Clinical features
Dogs with MH generally appear completely healthy until exposed to a triggering factor, such as specific anesthetic agents. When triggered, symptoms may develop within minutes and include extremely high body temperature, muscle stiffness, rapid breathing, irregular heart rhythm, and collapse. The reaction is rapid and can be life-threatening without the immediate discontinuation of the anesthetic and emergency care. MH can occur at any age, but clinical signs are most often seen during surgical procedures involving general anesthesia.
References
Pubmed ID: 11575546, 15474681
Year published: 2001
Omia ID: 621
Omia variant ID:
Turnaround information
- 15 working days