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Dog DNA testing illustration

Leukoencephalomyelopathy (LEMP) – Rottweiler and Great Dane

Code: H417

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Leukoencephalomyeolopathy (LEMP) is a neurological disease that affects the central nervous system, affecting coordination and gait.

General information

Leukoencephalomyeolopathy (LEMP) is a neurological disease that affects the central nervous system, affecting coordination and gait. The variant of the disease in this test occurs in the Great Dane and Rottweiler, and is caused by a recessive mutation to the gene LEMP. Another variant has been observed in the Leonberger.

Specifications

Breeds

Great Dane, Rottweiler
Gene

NAPEPLD
Chromosome

18
Mutation

c.345_346insC
Organ

Nervous System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Autosomal Recessive
Also known as

LEMP

Clinical features

Onset of LEMP occurs in juvenile dogs. Symptoms include slowly worsening gait abnormalities such as paw "knuckling", dragging of the paws, and hypermetria (overstepping while walking) of the front legs. The disease progresses over a matter of months.

References

Pubmed ID: 29643404

Year published: 2018

Omia ID: 1788

Omia variant ID:

Turnaround information

  • 15 working days