Curly Coat (c2) – Dog
Code: H681
Short description
An incomplete dominant mutation to the keratin gene KRT71 is responsible for the growth of a curly rather than straight coat in certain dogs.
General information
An incomplete dominant mutation to the keratin gene KRT71 is responsible for the growth of a curly rather than straight coat in certain dogs. The variant analysed in this test, designated as c^2, is found in breeds such as the Bichon Frise, Chesapeake Bay Retriever, Curly Coated Retriever and Lagotto Romagnolo. A closely related variant, designated as c^1, is originally found in the Portuguese Water Dog, though appears in many other breeds.
Specifications
| Breeds | Bichon Frise, Chesapeake Bay Retriever, Curly-coated retriever, Irish Terrier, Lagotto Romagnolo, Spanish Water Dog |
|---|---|
| Gene | KRT71 |
| Chromosome | 27 |
| Mutation | c.1266_1273delinsACA |
| Organ | Integumentary System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Incomplete Dominant |
Clinical features
Affected dogs with two mutated alleles have a curly-haired coat instead of a straight coat. Animals that carry one mutated allele have an in-between phenotype: a wavy coat. Coats must be of sufficient length to curl in the first place.
Additional information
There are some indications that the variant possibly represents a genetic risk factor for some forms of follicular dysplasia in dogs.
References
Pubmed ID: 30444027,30456859
Year published: 2019
Omia ID: 245
Omia variant ID:
Turnaround information
- 15 working days