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Dog DNA testing illustration

Haemophilia A – Rhodesian Ridgeback

Code: H931

74,72 €

Sample details

One test – one sample. Animal and owner details are optional.

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Short description

Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs.

General information

Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs. Caused by an X-linked recessive mutation to the gene F8, the disease strongly impairs the blood’s ability to clot, which can lead to severe symptoms such as spontaneous internal bleeding, or uncontrolled bleeding after injury or surgery. This specific variant of the disease occurs in the Rhodesian Ridgeback. Related variants are also found in the Irish Setter and Miniature Schnauzer, Boxer, Old English Sheepdog, and the German Shepherd.

Specifications

Breeds

Rhodesian Ridgeback
Gene

F8
Chromosome

X
Mutation

c.4824_25ins221
Organ

Cardiovascular System
Specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

X-Linked Recessive
Also known as

FVIII

Clinical features

Common clinical signs in dogs included: bleeding from the mouth, subcutaneous and intramuscular haematomas and lameness.

References

Pubmed ID: 33494213

Year published: 2021

Omia ID: 437

Omia variant ID:

Turnaround information

  • 15 working days