MDR1 Multi Drug Resistance – Cat
Code: K423
Short description
Multi Drug Resistance 1 (MDR1), sometimes known as Ivermectin Sensitivity, is a disorder that affects the blood-brain barrier.
General information
Multi Drug Resistance 1 (MDR1), sometimes known as Ivermectin Sensitivity, is a disorder that affects the blood-brain barrier. As a result, affected animals can be in effect poisoned when given certain drugs as part of standard veterinary procedures. In cats, a variant of the disease is caused by a recessive mutation to the gene ABCB1.
It is estimated that this mutation occurs in approximately 4% of domestic cats.
Specifications
| Breeds | All Breeds |
|---|---|
| Gene | ABCB1 |
| Chromosome | A2 |
| Mutation | c.1930_1931delTC |
| Organ | Nervous System |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | MDR1 |
Clinical features
Affected cats are likely to experience adverse reactions (central nervous system toxicity) to P-glycoprotein substrate drugs such as ivermectin, imidacloprid and selamectin.
References
Pubmed ID: 25660379
Year published: 2015
Omia ID: 1402
Omia variant ID:
Turnaround information
- 15 working days