Curly Coat with or without Hypotrichosis (SP6- and KRT25-related) – Horse
Code: P331
Short description
A curly coat in horses, known particularly as the distinctive trait of the American Bashkir Curly Horse, is caused by a complex interaction between two separate genes, KRT25 (P317) and SP6 (DNA test P330).
General information
A curly coat in horses, known particularly as the distinctive trait of the American Bashkir Curly Horse, is caused by a complex interaction between two separate genes, KRT25 (P317) and SP6 (DNA test P330). These same genes can also cause hypotrichosis: a loss of tail and mane hair.
A horse with a genotype with GG and CC (GC/GC) is entirely unaffected, and will develop a straight coat with normal thickness. A genotype of GC/GT or GT/GT causes a curly coat. A genotype of GC/AT or GC/AC causes curly coat and incomplete hypotrichosis (scanty tail). Finally, a genotype of AC/AC causes a curly coat with complete hypotrichosis (string tail).
Specifications
| Breeds | American Bashkir Curly, American Quarter Horse, Missouri Fox Trotter, Paso Fino, Tennessee Walking Horse, American Paint Horse, Appaloosa, Arabian, Morgan, Percheron |
|---|---|
| Gene | KRT25; SP6 |
| Organ | Integumentary System |
| Specimen | Hair, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Co-Dominant |
| Chromosome | 11 |
| Year Published | 2018 |
Clinical features
A curly coat in horses presents as short, coarse curls or waves. Horses with incomplete hypotrichosis, or “scanty tail”, retain some degree of hair growth on their mane and tail. Horses with complete hypotrichosis, or “string tail”, have no mane and a bare tail.
References
Pubmed ID: 29686323; 29141579
Omia ID: 245; 2175
Turnaround information
- 15 working days